PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone

Low dose prednisolone for treatment of RA.

We thank Dr Smith for alerting readers and us to the existence of his excellent paper that came out after our study was done and during the preparation of our manuscript. Our study described asymptomatic subjects, a somewhat different group from that in Dr Smith’s study—namely, patients with unexplained knee pain with clinically and arthroscopically normal knee joints. It is fascinating that in...

Comparison of the Efficacy of Combination Therapy of Prednisolone - Acyclovir with Prednisolone Alone in Bell’s Palsy

OBJECTIVE Bell's palsy is a rapid onset, usually, unilateral paralysis of the facial nerve that causes significant changes in an individual's life such as a decline in personal, social, and educational performance. This study compared efficacy of combined prednisolone and acyclovir therapy with prednisolone alone. MATERIALS & METHODS This study is a randomized controlled trial conducted on 43...

Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration

BACKGROUND In Europe, synthetic corticosteroids are not allowed in animal breeding for growth-promoting purposes. Nevertheless, a high prevalence of non-compliant urine samples was recently reported for prednisolone, however, without any indication of unauthorized use. Within this context, 20β-dihydroprednisolone and the prednisolone/cortisol ratio have been suggested as potential tools to disc...

Specific micro-radioimmunoassay for prednisolone in serum.

Use of an 125I radioimmunoassay involving antiserum coupled to magnetizable cellulose, after prednisolone-21-phosphate interference is removed by dichloromethane extraction at pH 7.4 and endogenous glucocorticoid interference is removed by selective chemical derivatization with Girard's Reagent T [(carboxymethyl)trimethylammonium chloride hydrazide], allows determination of prednisolone in 10 m...

Running Head: PREDNISOLONE VERSES DEXAMETHASONE